Recently, there has been a growing interest in the potential of magic mushrooms to assist in treating various mental health conditions, particularly depression. A developing trend involves taking a consistent dose of around 25 mg of the active ingredient, available for purchase at a mushroom dispensary. This dosage shows promising signs of providing relief and could complement traditional depression treatments.
A group of scholars conducted research suggesting that psilocybin, the active compound in magic mushrooms, has demonstrated promising results for depression treatment.
Main Points:
- Psilocybin may improve symptoms of depression in as little as eight days.
- The side effects of Psilocybin are typically mild to moderate and are generally well-tolerated.
- A dose of 25mg of psilocybin can bring about changes in perception, mood alterations, increased creativity, and a sense of unity.
A Single Dose May be Sufficient
A recent study employed a rigorous methodology, using a randomized, multi-blinded design to compare a single dose of psilocybin with an active placebo (niacin). This study evaluated the onset, duration of benefits, and safety of psilocybin over a period of six weeks.
The Participants
The study targeted individuals aged 21 to 65 who met the criteria for Major Depressive Disorder (MDD) as defined in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) and were undergoing a depressive episode with a duration of at least 60 days at the time of the study.
The Procedure
Participants received either a single 25-mg oral dose of psilocybin or a 100-mg dose of niacin. Niacin acted as an active placebo, eliciting an immediate physiological response (flushing) to maintain the blinding integrity.
Both the psilocybin and the niacin placebo were given following a standard “set and setting” protocol. The preparatory sessions, held with two facilitators, lasted between 6 and
The dosing session typically lasted between 7 and 10 hours in a relaxed environment. Participants were urged to contemplate their experiences four hours after the dosage.
Insights from the Study
Depression symptoms started to diminish just eight days after psilocybin was administered. This promising outcome remained consistent during the six-week follow-up period. The response and remission rates, according to the Montgomery-Asberg Depression Rating Scale (MADRS), were higher than other psilocybin studies and those related to Treatment-Resistant Depression.
When compared to niacin, psilocybin showed better psychosocial functioning. Its usage indicated potential in numerous areas, like reducing the overall severity of the disease, lessening anxiety, decreasing self-reported depressive symptoms, and improving life quality.
The compound was well tolerated by most individuals, with only minor or moderate side effects, mainly after the initial dose. However, psilocybin treatment resulted in more frequent and severe adverse effects than niacin, which is consistent with our current understanding of its effects.
The scientists noted that psychedelics like psilocybin could trigger side effects that conventional rating scales may not always capture, or they could reveal previously undetected psychiatric disorders, even while effectively treating specific syndromes.
What Does a 25-mg Dose Mean?
A standard psychedelic dose usually falls between 15 to 25 milligrams of psilocybin (equivalent to 1.5 to 2.5 grams of dried mushrooms). This is the typical dosage for those seeking the full psychedelic impact of magic mushrooms.
This dose can lead to changes in perception, mood alterations, increased creativity, and a feeling of unity with the environment. While slight visual effects may occur, intense hallucinations are rare. It’s like entering a vivid dream world where reality blends effortlessly with a mesmerizing mix of visual and auditory sensations.
Euphoric feelings often express themselves through dance, gentle movements, or simply letting go to the psychedelic rhythm. The experience usually lasts from 4 to 8 hours. At this level, visual distortions may become more pronounced, with patterns seeming to move and change, and the surroundings appearing to pulsate with energy.
This dose can be controlled, but it necessitates a structured environment and a positive mindset. It promises a journey filled with wonder and awe, motivating you to delve into the realm of consciousness.
Approach with measured excitement.
- A noticeable increase in color sensitivity.
- Visual aberrations, such as objects appearing to move or “breathe”.
- Experiencing synesthesia, like “seeing sounds” or “hearing colors”.
- Developing a deep appreciation for music.
- Occasional fits of laughter.
- Changes in the sense of touch.
- Indulging in introspection.
- Feeling intense joy.
- Experiencing alterations in time perception.
- Increased heart rate and blood pressure.
Variety of Products Offered at Magic Mushroom Stores
Magic mushroom retailers provide an array of psilocybin-infused products. They offer a wide variety of items including dried mushrooms, edibles, capsules, drinks, and more. Dried mushrooms, in particular, are a popular choice.
Health Canada recognizes over 200 species of magic mushrooms, with Psilocybe cubensis being a commonly sold strain. This strain comes in diverse varieties, providing a broad array of choices to consumers, similar to those found at cannabis dispensaries.
Other Mushroom Products:
| Edibles | Food products such as gummies and chocolates infused with psilocybin. The dosage is made clear as it is indicated by the manufacturer on a per-serving basis. |
| Capsules | These are flavorless and can be easily integrated into your daily wellness routine. They contain minimal amounts to provide a gentle boost to your regimen. |
| Beverages | Similar to edibles but in a drinkable form. These are versatile, available as chocolate, coffee, or tea. |
Determining Your Dosage at Magic Mushroom Dispensaries
Even though magic mushrooms are not typically used to treat depression, Canada has taken a progressive step by authorizing the medical use and testing of psilocybin, a Schedule I substance under the Controlled Drugs and Substances Act, for certain patients suffering from severe major depressive disorder. This move could potentially benefit tens of thousands
Individuals grappling with anxiety and depression may evaluate alternative therapeutic avenues through clinical trials.
Commonly Asked Questions
Can I buy psilocybin from a medicinal mushroom dispensary?
A medicinal mushroom dispensary typically houses products like Reishi, Turkey Tail, and Lion’s Mane. If you’re intrigued by the mushroom realm, consider an online magic mushroom dispensary as your primary source. Such dispensaries offer a range of mushroom products, including dried mushrooms and various psychedelic substances.
Is a dosage of 25 mg suitable for depression treatment?
Ongoing research is investigating the optimal psilocybin dosages for managing depression. Some studies are focusing on smaller dosages, while others examine larger quantities of psilocybin. A potential approach might be to begin with a microdose and gradually increase it.
Can I buy shrooms in Toronto?
Online mushroom sellers ensure the convenience of purchasing from anywhere in Canada. Regardless of your province or city, these online establishments promise delivery right to your door.
What is the most budget-friendly product at an online mushroom store?
Dried mushrooms are often the first choice for shoppers due to their availability in various amounts. The price may fluctuate based on whether you require a small quantity like 1 gram or intend to buy in bulk. Although edibles and other products are fairly priced, they may not be as economical as dried mushrooms.
Can a single shroom dose help alleviate depression?
Some studies indicate that a one-time use may be enough to lessen depression symptoms. However, it’s important to remember that study participants also received talk therapy along with the treatment. The combination of psychedelic therapy and therapeutic sessions appears to yield the most effective results.
About the Author
This piece was penned by Charles L. Raison et al.; Jeremy D. Coplan, MD and Dorothy P. Reddy, MD; Albert Garcia-Romeu, Frederick S Barrett, Theresa M Carbonaro, Matthew W Johnson, and Roland R Griffiths; Vince Polito
Richard J. Stevenson, Rebecca Smausz, Joanna Neill, and John Gigg also contributed to this work.
Affiliated Organizations:
- The Usona Institute, based in Fitchburg, Wisconsin
- SUNY Downstate Medical Center, located in Brooklyn, New York
- Neurogenesis Clinics in Brooklyn, New York
- The Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine in Baltimore, MD, USA
- Center for Psychedelic and Consciousness Research at Johns Hopkins University School of Medicine in Baltimore, MD, USA
- Department of Neuroscience at Johns Hopkins University School of Medicine in Baltimore, MD, USA
- Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine in Baltimore, USA
- Department of Cognitive Science at Macquarie University in Sydney, Australia
- Department of Psychology at Macquarie University in Sydney, Australia
- The Division of Neuroscience and Experimental Psychology at The University of Manchester’s Faculty of Biology, Medicine and Health in Manchester, UK
- The Division of Pharmacy and Optometry at The University of Manchester’s Faculty of Biology, Medicine and Health in Manchester, UK
- Medical Psychedelics Working Group associated with Drug Science, UK
